FDA Places Clinical Hold on VYNE’s VYN202 Phase 1b Trial for Plaque Psoriasis

VYNE Therapeutics Inc. announced today a pause in development in its clinical pipeline: the US FDA has issued a verbal notice of clinical hold on the company’s ongoing phase 1b trial evaluating VYN202, an investigational oral bromodomain and extra-terminal …

Low-Grade Inflammation Increases Risk of Psoriasis, Especially in Severe Cases: Study Finds

Denmark: A large population-based study published in the British Journal of Dermatology, involving more than 100,000 individuals, has found that low-grade systemic inflammation is significantly associated with an increased risk of developing psoriasis, …

Vyne Crashes After Safety Signal in Dogs Puts Hold on Clinical Trial of Plaque Psoriasis

The FDA has slapped a clinical hold on a Phase Ib trial of Vyne Therapeutics’ investigational BET blocker VYN202 for plaque psoriasis, the biotech revealed Friday. The regulatory freeze stems from testicular toxicity observed in dogs during a toxicology …

Biologic Efficacy in Psoriasis Comparable Among Older, Younger Patient Cohorts

The efficacy of biologic treatments for psoriasis is comparable between older and younger patients, new findings suggest, although drug survival rates among older patients are lower in the treatment period.1 These findings were the results of new research …

Dosing Interval Differences in Psoriasis and Psoriatic Arthritis Treatment

Examining the Relationship Between Psoriasis and Psoriatic Arthritis

Rising Costs of Biologics for Plaque Psoriasis Highlight Savings Potential

The cost of biologic treatments for patients with plaque psoriasis more than doubled from 2007 to 2021, according to a new study, despite the availability of lower-cost alternatives.1 Researchers found that switching to the most affordable biologic in each …

Study Identifies Risk Factors Linked to Excessive Sun Exposure in Those with Psoriasis

New findings suggest excessive sun exposure (ESE) among patients with psoriasis is more likely among patients who are female, younger, of average weight, of intermediate skin phenotype, and who have a history of phototherapy.1 These findings resulted from …

Dosing Interval Differences in Psoriasis and Psoriatic Arthritis Treatment

Panelists discuss how although SPECTREM was groundbreaking as the first randomized controlled trial specifically targeting moderate psoriasis in high-impact areas, other valuable evidence exists including subgroup analyses from pivotal trials of …

Psoriasis- Signs, Symptoms and types in Children

Abstract:  Psoriasis is a chronic, relapsing inflammatory skin disorder that can significantly affect children both physically and emotionally1. Characterized by erythematous, scaly plaques, pediatric psoriasis often presents with different patterns than …